Yes you can, but only if you invest and purchase another business. Owning a real and operational business that benefits the U.S. economy is the reason behind the E-2 Treaty Investor Visa. Without the existence of a business, there is no E-2 Visa. Owning a business is mandatory.
If you already have an E-2 visa and plan to sell your business, consult an immigration attorney and a business expert before selling your business in order to reassure that you do not violate the E-2 visa requirements while in the U.S. Any unlawful presence in the U.S. will impact your ability to apply for any future visas.
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