Healthcare is one of the largest industries in the United States. As the population ages and health needs grow, demand continues to rise in areas like elder care and mental health. For E-2 visa applicants, this creates room to create a healthcare-related business that meets both immigration requirements and community needs.
Why Healthcare Is a Strong Sector for E-2 Investors
Both public and private investment in healthcare remain high. According to McKinsey, the industry’s profit potential could grow from $583 billion in 2022 to $819 billion by 2027, with an average growth rate of 7 percent per year.
Private investment in U.S. healthcare remains high. According to PwC, there were 445 healthcare deals announced in early 2025. Most involved the sale or purchase of businesses such as outpatient clinics, mental health providers, and home-based care services. Behavioral health was the fastest-growing area. Transactions involving mental health and autism service providers rose by more than 35 percent compared to the same time last year. Deals for autism care businesses alone doubled, reaching their highest level since 2020.
Healthcare-related real estate is also showing signs of recovery. Cushman & Wakefield reports that buyer activity for medical office buildings picked up in 2025 as interest rates began to settle.
Types of Healthcare Businesses That May Qualify
To meet E-2 visa requirements, the investment must be active, not passive. The business should generate income and support U.S. jobs.
Healthcare businesses that qualify include:
- Home care agencies (non-medical personal support)
- Behavioral health clinics
- Medical billing or healthcare administration firms
- Outpatient therapy and rehabilitation centers
Support from Public Health Policy
The Centers for Disease Control and Prevention (CDC) lists public health goals that include chronic disease prevention, mental health support, and better access to care. These goals are backed by local and federal programs that can help certain healthcare providers grow and stay funded.
Getting Started
If you’re considering an E-2 investment in healthcare, here are five steps:
- Study local demand and service gaps
- Choose a model that fits your experience and budget
- Create a full business plan with staffing and licensing details
- Commit capital to a real, functioning business
- Apply with proof of investment, ownership, and employment potential
Sources
- McKinsey. What to Expect in U.S. Healthcare in 2025 and Beyond. https://www.mckinsey.com/industries/healthcare/our-insights/what-to-expect-in-us-healthcare-in-2025-and-beyond
- PwC. Health Services: U.S. Deals Outlook. https://www.pwc.com/us/en/industries/health-industries/library/health-services-deals-outlook.html
- Cushman & Wakefield. Healthcare Capital Markets Outlook. https://www.cushmanwakefield.com/en/united-states/insights/healthcare-capital-markets-outlook
- CDC. National Health Initiatives, Strategies & Action Plans. https://www.cdc.gov/public-health-gateway/php/communications-resources/national-health-initiatives-strategies-action-plans.html